This week's depression links - 2/28/08

• Antidepressants Only Benefit The Severely Depressed, Study

  the difference in effect between drug and placebo was only clinically significant in those patients who were very severely depressed at the start of their treatment and this effect was more likely due to a weaker response to the placebo than a stronger re

• Ask your dentist: dental health, inflammation, and depression :: Rebuild from Depression Blog

  There are schools of thought that “inflammation” is the underlying cause or at least common bond between heart disease, diabetes, and depression.

• Bout of depression good for soul

  This reminds me of the old story about a person ingesting a small amount of arsenic every day in order to build an immunity to it. I don't know if the story is true and I am less certain that it's a good idea.

• Depression the great excuse of our times | NEWS.com.au

  Depression has become the great excuse of our times and what is a genuine condition has been corrupted into a nifty carry-all excuse.

• Modafinil augmentation of SSRI therapy in patients...[CNS Spectr. 2006] - PubMed Result

  CONCLUSION: Twelve weeks of modafinil augmentation relieved excessive sleepiness, reduced fatigue, and improved patients' overall clinical condition, including mood.

• PLoS Medicine - Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

  Drug–placebo differences in antidepressant efficacy increase as a function of baseline severity, but are relatively small even for severely depressed patients. The relationship between initial severity and antidepressant efficacy is attributable to decr

• Psychologist Seeks Stone Age Solutions to Depression

  What the author doesn't mention is that the life span of our stone age ancestors was probably in the mid-30s.

• Psychology Today: Lose Some, Win Some

  Apparently, skipping a night's sleep can alleviate symptoms in severely depressed patients. It doesn't work and even has a negative effect on mild-moderate depression patients.

• Researchers Explore The Antidepressant Effects Of Ketamine

  Ketamine, a drug used in general medicine as an anesthetic, has recently been shown to produce improvements in depressed patients within hours of administration.

• The Medicated Americans: Antidepressant Prescriptions on the Rise: Scientific American

  A study of antidepressant use in private health insurance plans by the New England Research Institute found that 43 percent of those who had been prescribed antidepressants had no psychiatric diagnosis or any mental health care beyond the prescription of

• The gut-brain barrier in major depression: Intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression – Source: Neuro Endocrinology L

  It is suggested that patients with MDD should be checked for leaky gut by means of the IgM and IgA panel used in the present study and accordingly should be treated for leaky gut.

• What the media misses about antidepressants

  A different view of the recent news that antidepressants are often no more effective than a placebo. In this writer's view, because patients respond uniquely to each medication, it's worth trying SSRIs on the chance that it might just save a life.

• Your Wandering Mind on Depression: A History of Depression (Part One)

  If you experience depression in early adulthood your risk for future depressive episodes increases with the number, severity and length of each depressive episode.

• » Blog Archive » Mindfulness with Jon Kabat-Zinn

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