Over the past few years, the FDA has required stronger warnings regarding an increased risk of suicide as a result of taking some anti-depressants. The reasons for the increased risk aren't clear. It could be that the meds trigger increased suicidiality (thoughts of suicide) or that the improved energy levels in some patients gives them the strength to act on those thoughts. The risk seems greatest when antidepressants are given to teenagers (or younger).
An unintended side-effect of the strong warnings is that doctors, primary-care physicians, at least, are reporting fewer cases of depression and prescribing meds less frequently. See Impact of U.S. antidepressant warnings still felt. (Overall anti-depressant use hasn't fallen, just those prescribed by PCPs.)
Again, the reasons for this shift aren't understood very well, but appear to be related to concerns among doctors and patients (and/or patients' parents) that the increased risk isn't worth the potential benefit.
There are a lot of legitimate concerns regarding medications and, particularly, the over-prescribing of meds in the past decade. That said, this report also shows that physicians are not prescribing alternatives, such as older types of anti-depressants or counseling therapies. As a result, fewer people are being diagnosed with and treated for depression.
How bad is this? Not sure. Suicide rates during this period haven't changed significantly.
Wednesday, June 3, 2009
Black box warnings and reduced depression diagnoses
Posted by Karl Hakkarainen at 10:23 AM
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